TeloRegen Science | Telomere Therapy for Regenerative Medicine

What are Telomeres?

Telomeres are the end part of chromosomes, which shorten as cells divide, acting as an aging clock for cells. Telomere Therapy regenerates the telomeres of cells, restoring youthful cellular function throughout the body. Our vision is more decades of youthful health for everyone.

Telomere Reset Therapy

A practical Telomere Reset Therapy would mean that we would live with youthful health and appearance through many more decades than we do now. Not forever. There's still likely biological limits on how long we can live.
But we expect that with TeloRegen and their Telomere Reset Therapy you could live a life of health, vigor, contribution, and fulfillment for many more decades than we do now. Our patent application for a practical Telomere Reset Therapy was just recently published.

How Can This Be Real?

Three key advances have been necessary to be able to successfully develop a Telomere Reset Therapy for the diseases of aging and to improve cellular repair and regeneration after trauma and disease:
  • Understanding the root process that causes our cells to age and decline.

  • Discovering what is required to reverse that cell aging process.

  • Working out how to safely and effectively deliver the therapy to cells throughout a living human being.

Telomere

STEP 1 - Understanding Cell Aging

The root cause

The first step is to understand the root cause of aging at the cellular level. Scientific understanding of aging has progressed rapidly in recent decades. It is common to think that we age from the passage of time and from the accumulation of wear and tear.

“As a car gets older, it accumulates dings and rust from all of the stressful miles traveled. Parts begin to fail, joints creak, things start to wear and fall apart. The “Wear and Tear” model of aging occurs in humans. What if you were a very smart car owner? What if you kept replacing every single piece of that car with shiny new parts throughout a regular basis: new tires, new fenders, new paint, new seats, new engine, and so on? Is that car old or new? It would look new, it would operate like new – it would be new – rapid replacement process outpaced the rate of deterioration.”

Rapid cell replacement is what a healthy body does when young. Every cell constantly replaces its molecular machinery and structures on a very rapid schedule. Biologists have discovered that this rapid maintenance process is programmed to gradually slow down, until repair, replacement, and function eventually cease.

The programmed mechanism that drives cell aging is called telomere shortening. That tail shortens with each cell division, as cells divide and multiply to grow, repair, and replace tissues. The shorter the telomere tail becomes the more we physically age.

STEP 2 - The Telomerase

Re-lengthen the telomeres inside the cell nucleus

Cells also have a mechanism for re-lengthening telomeres. The body’s protein enzyme that does this is called telomerase. It is the cell’s own molecular machine for re-extending telomeres. Some telomerase is present in our stem cells at low levels, rebuilding telomere lengths by just enough to keep our proliferative cells functioning, on average, for several decades.

All cells have the gene for making telomerase, but only a few cells such as stem cells and reproductive cells actually make telomerase. Ordinary body cells, which make up the vast majority of the body, do not express telomerase. Providing just one copy of the telomerase enzyme within a cell starts lengthening telomeres. Introducing multiple copies is even more effective.

Delivery of Telomere Therapy

STEP 3 - Delivery of Telomere Therapy

A Safe and Natural mechanism for delivering telomerase
without a virus

The therapeutic is delivered inside of liposomes. Liposomes are tiny bubbles made out of phospholipids. The walls of our cells are also made out of phospholipids. The liposomes are injected into the bloodstream and are carried via the circulatory system to cells throughout the body.

The outer surface of each liposome is studded with monoclonal antibodies, which target the insulin receptors found on the surface of cells. The insulin receptors attach to the liposomes and drag them first across the capillary walls (transcytosis) and then into cells throughout the body, including across the blood-brain barrier.

Insulin targets the nucleus, which means that the liposome is then dragged through the nuclear pores and into the cell nucleus, where it releases its cargo.

This “Trojan Horse Liposome” delivery method was developed by Armagen of California (http://armagen.com) and demonstrated (so far up to primates) to be effective for delivering large and small molecule cargoes throughout living organisms, including across the blood brain barrier, which is usually very difficult to do.

Patent Citations

Patent # WO2015100269 A3
Cited Patent Filing date Publication date Applicant Title
US20020025313 26 Feb 2001 28 Feb 2002 Micklus Michael J. Targeting of liposomes to the blood-brain barrier
US20030143228 29 Oct 2002 31 Jul 2003 Baylor College Of Medicine Human telomerase reverse transcriptase as a class-II restricted tumor-associated antigen
US20070065415 16 Sep 2005 22 Mar 2007 Kleinsek Donald A Compositions and methods for the augmentation and repair of defects in tissue
US20110177043 22 Sep 2009 21 Jul 2011 Agency for science,technology and research(A*star) Method of improving differentiation of chondrogenic progenitor cells
US20110243910 7 Jul 2009 6 Oct 2011 Japan Health Sciences Foundation mammalian rna dependent rna polymerase
US20130202684 31 Aug 2011 8 Aug 2013 Lichtstrasse Pegylated liposomes for delivery of immunogen encoding rna